Monoclonal antibodies continue to show their ability to rid the brain of amyloid plaques. Trouble is, those antibodies need to be injected on the regular to keep taking down their targets in the brain ...

Oxytocin is a peptide hormone involved in social bonding, reproduction, and childbirth. Defects in oxytocin biology have been implicated in neurodegenerative disorders ranging from frontotemporal ...

This is a knock-in (KI) mouse model carrying a L444P mutation in the endogenous Gba (glucocerebrosidase [GC] or acid β-glucosidase) gene (Liu et al., 1998). The GBA1 protein is the lipid-degrading ...

In Pick’s disease, as in Alzheimer’s disease and frontotemporal dementia, tangled tau spells trouble. In this subtype of FTD, abnormal clumps of three-repeat tau called Pick bodies abound in neurons.

reactive to aa 1-16 of Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms ...

The center collects, processes, stores, and distributes samples, including longitudinal samples, from its research participants. Collections are taken from donors in their 40s to late 90s in a limited ...

This humanized IgG1 antibody inhibits an immune checkpoint protein called programmed death ligand, aka PD-L1, stimulating the immune system. Checkpoint inhibitors, including other antibodies, are ...

Paper Citations Demars M, Hu YS, Gadadhar A, Lazarov O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res. 2010 Aug 1;88 ...

Is it three steps forward one step back for blood tests? At the 18th Clinical Trials on Alzheimer’s Disease, held December 1–4 in San Diego, new data on the FDA-approved Fujirebio Lumipulse plasma ...

The days when reading a few papers brought scientists up to speed on the developments in their field are gone. Now scientists face mounting volumes of deeply complex datasets, and not remotely enough ...

Scientists have spotted a new variety of riled-up microglia that drives swelling in the human brain. In the November 18 Neuron, researchers from China led by Haixiao Liu, Shunnan Ge, and Yan Qu at ...

Transcribe, splice, and everything’s nice—at least in healthy people. Scientists are finding that abnormal splicing, and genetic variants that cause it, may kickstart some neurodegenerative diseases.