The 49ers have a strong chance to make the playoffs despite having the toughest remaining schedule. Here's what you need to know.

The 49ers (10-4) face NFL rushing leader Jonathan Taylor and unretired QB Philip Rivers on Monday night in Indianapolis ...

On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss San Francisco's ability to win each of their final three games to ...

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their ...

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 ...

Kyle Shanahan, Christian McCaffrey and more speak to reporters before San Francisco’s practice on Thursday in Santa ...

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been ...

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL ...

Highlighting the San Francisco 49ers interns, their career paths, roles within the organization, and advice for aspiring ...