The San Francisco 49ers are 10-4 and travel to face the Indianapolis Colts on Monday. We break down how they can clinch a ...

Playoff fantasy implications loom as 49ers clash with Colts. Identify your waiver wire heroes and crucial lineup decisions ...

The 49ers (10-4) face NFL rushing leader Jonathan Taylor and unretired QB Philip Rivers on Monday night in Indianapolis ...

The 2025 draft class is starting to look disappointing for the San Francisco 49ers. On Saturday, the Niners placed rookie ...

For the second time since they traded him, the San Francisco 49ers will face DeForest Buckner and the Indianapolis Colts. Or ...

Aiyuk hasn't played for the 49ers all season but drove by the team facilities in a video posted to his YouTube account.

San Francisco 49ers wide receiver Ricky Pearsall will miss Monday night's game against the Indianapolis Colts after ...

The San Francisco 49ers will go into a vital Monday Night Football matchup vs. the Indianapolis Colts without two starters.

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the ...

Here's a look at the studs and duds (and those in between) from the Tennessee Titans' 37-24 loss to the San Francisco 49ers ...