Playoff fantasy implications loom as 49ers clash with Colts. Identify your waiver wire heroes and crucial lineup decisions for this critical matchup.

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

The 49ers (10-4) face NFL rushing leader Jonathan Taylor and unretired QB Philip Rivers on Monday night in Indianapolis against the Colts (8-6).

There's a case that 2025 has been Shanahan's best coaching season to date and his candidacy should gain steam for Coach of the Year.

The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their winning streak to five games as they push toward a return to the NFL postseason. With a victory on Monday night at Lucas Oil Stadium, the 49ers would...

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been nearly perfect in both. In those two g

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL madness

Highlighting the San Francisco 49ers interns, their career paths, roles within the organization, and advice for aspiring professionals.

San Francisco 49ers wide receiver Ricky Pearsall will miss Monday night's game against the Indianapolis Colts after re-injuring his knee.

For NFL WAG Sydney Warner, football season is about as busy as it can get this year. With her husband, San Francisco 49ers linebacker Fred Warner, Sydney already has one kid under two — her son Beau — and now, the couple has another on the way!